Greenville is the county seat of and largest city in Greenville County^GR6 South Carolina, United States. Greenville, with its historic homes and modern office towers, has been described as where "Old South" meets "New South". Greenville's Combined Statistical Area (CSA) population is 1,185,534 according to 2005 estimates by the U.S. Census Bureau. Greenville County is the most populous in the state at 407,383, but because its city limits enclose less than 30 square miles, the population of the city proper is 56,002 (2000 U.S. Census). The city of Greenville is one of the most densely populated municipalities in the state, while Greenville County has the highest population density of any county in South Carolina. Greenville is the primary city of "The Upstate" of South Carolina, an area that includes the six counties of northwestern South Carolina along the borders of North Carolina and Georgia.

Greenville is on Interstate Highway I-85 between Atlanta and Charlotte, with I-385 and I-185 servicing other areas of the metro. I-26 is about 30 miles to the northeast in Spartanburg.