Poughkeepsie is a city in New York, USA and serves as the county seat of Dutchess County, located in the Hudson River Valley roughly midway between New York City and Albany. As of the 2000 census, the city of Poughkeepsie had a population of 29,871. The name derives from a Native American word (roughly U-puku-ipi-sing), meaning "campsite by small water," referring to a stream feeding into the Hudson River.

Poughkeepsie is located in the western part of Dutchess County, bordered on the west by the Hudson River and in all other directions by the Town of Poughkeepsie. Poughkeepsie calls itself the "Queen City of the Hudson."

IBM has a large campus in Poughkeepsie (a facility still referred to by many as IBM's "Main Plant"). A factory on site once built the IBM Stretch Computer as well as later machines such as the IBM System/360 model 195. However, the main IBM campus is actually in the Town of Poughkeepsie, a separate municipality from the City, though both are general viewed as one place.