Lexington is a city in Dawson County, Nebraska, United States. The population was 10,011 at the 2000 census. It is the county seat of Dawson County^GR6. Lexington is located in southern Nebraska, on the Platte River, southeast of North Platte. It sits along the route of U.S. Route 30 and the Union Pacific Railroad. In the 1860s it was the location of a stop along the Pony Express.

The town is noted for its relatively high proportion of Mexican-Americans for central Nebraska (over 50% over the town population), reflected in the Spanish language-businesses in downtown and along U.S. 30.