Grand Junction is a city in Mesa County, Colorado, USA. The population was 41,986 at the 2000 census. It is the county seat of Mesa County^GR6. The city is largest population center on the Colorado Western Slope, unofficially serving as the capital of the region. The local television stations serve as a major media source for the region, in the way that those in Denver do for the Colorado Front Range to the east.

The city located along the north side of Colorado River where it receives the Gunnison River from south. The name "Grand" refers to the historical name of the upper Colorado River used by locals in the late 19th and early 20th century. The city sits near the mid-point of a 30-mile (48 km) arcing valley, known as the Grand Valley, that is a major fruit growing region, historically home to the Ute people and settled by white farmers in the 1880s. In recent years, several wineries have been established in the area as well. The Colorado National Monument, a series of canyons and mesas similar to the Grand Canyon, overlook the city. Interstate 70 connects the city eastward to Glenwood Springs and Denver.